Two independent papers advance genome‑editing approaches: a review outlining progress and prospects for gene editing in collagen disorders and a methods paper describing Prime‑Editing‑Based Inversion with Enhanced Performance (PIE), which enables large‑scale chromosomal inversions in mammalian cells. The collagen review (Gene Therapy) synthesizes CRISPR and gene‑replacement strategies under investigation for structural connective‑tissue diseases, mapping translational paths and remaining technical hurdles. PIE provides a new technical capability for generating large genomic rearrangements that have been difficult to model or correct, using prime‑editing principles to increase efficiency and precision. PIE’s capacity to produce controlled chromosomal inversions may accelerate disease modeling and therapeutic engineering for disorders driven by structural variants, while the collagen work frames near‑term clinical targets where editing could be curative.