Innovative gene editing technologies and genomic research unveil powerful new tools and insights. Novel electroporation methods enable gene function analysis in Japanese rhinoceros beetles. Comprehensive genome assembly of hexaploid sweetpotato illuminates its complex evolutionary origin. New T7-based hypermutation systems accelerate directed evolution of proteins within live cells. Updates in gene editing safety standards emerge from consortium efforts. Computer-based protein design advances custom enzymatic and therapeutic functions. Collectively, these developments enhance understanding of genetics and improve genome engineering capabilities.