Groundbreaking research has enhanced genome editing precision through novel microhomology-based DNA template design guided by deep learning algorithms, improving targeted DNA integrations in postmitotic cells. Innovations in prime editing technology, including twin pegRNA designs, enable corrections of larger genomic segments with a safer profile than traditional CRISPR cutting. Studies also reveal the occasional risks of base and prime editing causing unintended double-strand breaks. Complementary advances in anti-CRISPR proteins promise improved safety profiles for gene therapies.