Artificial intelligence is increasingly integrated into gene editing technologies. The innovative CRISPR-GPT system automates design and conduct of gene-editing experiments through large language model interactions, democratizing CRISPR research. Profluent’s AI-driven protein language models have generated highly functional genome editors surpassing natural variants in activity and specificity, indicating a new paradigm in programmable therapeutics. Complementing this, virtual AI labs simulate multidisciplinary research teams to accelerate scientific discovery in complex biological problems. These AI-enabled platforms may radically streamline experimental workflows and therapeutic design in the biotech landscape.