Scientists reported a gene-edited cell transplant that restored insulin production in a patient with type 1 diabetes. The transplanted insulin-producing cells were engineered to evade immune rejection and were implanted without long-term immunosuppression, according to the team that conducted the procedure. The report describes measurable endogenous insulin production and reduced exogenous insulin needs in the treated individual. The case represents a clinical milestone for cell-based therapies aiming to cure autoimmune diabetes. The study details device and cell-engineering approaches used to protect grafts from immune attack and documents short-term safety and biomarker changes post-transplant. Longer-term follow-up and controlled trials are required to determine durability, reproducibility, and generalizability of the approach.
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