Researchers adapted a previously developed gene‑drive strategy for an African mosquito strain and established a secure facility in Tanzania to test transmission‑blocking modifications against genetically diverse Plasmodium falciparum isolates. The antiparasitic construct, MM‑CP, expresses two antimicrobial peptides and was evaluated by feeding gene‑drive and helper strains on field‑derived parasites. Results published in Nature showed reduced oocyst growth, lower sporozoite output and delayed salivary gland migration, validating prior laboratory findings in a more representative parasite context. The study aims to bridge laboratory efficacy and field relevance ahead of further ecological and regulatory evaluation. Gene drives are genetic systems that bias inheritance to spread chosen traits through wild populations; this work separates antiparasitic effectors from drive components to evaluate transmission blockade in local mosquito genetics.