Researchers published mechanistic data showing that focused ultrasound transiently and reversibly opens the blood‑brain barrier by reorganizing tight junction proteins, offering a safer delivery route for CNS therapeutics. The study in Communications Engineering detailed how the technique preserves barrier integrity while allowing therapeutic access. The work provides a clearer mechanistic framework for ongoing clinical programs using ultrasound‑mediated BBB disruption and may inform parameter selection to balance delivery efficiency with safety in trials for neurodegenerative diseases and brain tumors.