Two independent studies highlighted ferroptosis as a central mechanism in both sepsis pathogenesis and gastric cancer therapy resistance. One paper describes how ferroptotic cell death pathways amplify inflammatory injury during sepsis, identifying lipid peroxidation and iron metabolism nodes linked to organ dysfunction. A second study links ferroptosis induction to overcoming drug resistance in gastric cancer, reporting biomarkers that predict susceptibility. Together, the reports expand ferroptosis from a cell‑death curiosity into a translational target across infectious and oncologic disease domains.