In a keynote at the GEN virtual summit, Feng Zhang, Broad Institute and Howard Hughes Medical Institute investigator, presented breakthroughs from his lab including novel gene editing delivery techniques using endogenous capsid proteins and prokaryotic injection systems. He also discussed TIGR RNA-programmable systems for advanced genome editing. Zhang emphasized nature’s inventive mechanisms, particularly bacterial-phage interactions, as sources for transformative therapeutic tools. He is co-founder of multiple biotech companies focused on genome editing, underscoring the translational trajectory of this research.