Researchers introduced a six-part framework intended to standardize how clinical trials define outcomes, specifying domain, measurement, metric, cutoff (when relevant), variable type, and time point. The authors tested the structure by applying it to 225 randomized controlled trials and 3,424 outcomes from ClinicalTrials.gov, aiming to improve whether reported outcomes are clearly prespecified and comparable across studies. The framework is designed for sponsors and trialists to tighten documentation and interpretation in protocols and results reporting. For the industry, it offers a concrete template that can reduce ambiguity in endpoints—particularly where multiple metrics and time windows can inflate interpretive drift. As trial diversity increases across regulatory regions and data types, this effort targets a bottleneck that affects endpoint reuse in registries, meta-analyses, and evidence generation for label expansions.