Scientists introduced Filter-aided expansion proteomics (FAXP), a technique that combines hydrogel tissue expansion with mass spectrometry to analyze proteins in formalin-fixed, paraffin-embedded (FFPE) specimens at subcellular resolution. FAXP addresses a long-standing obstacle in spatial proteomics: extracting high-resolution protein data from archived clinical samples. The method enables quantitative profiling across small tissue volumes while maintaining compatibility with standard pathology workflows. Authors present validation datasets showing improved depth and spatial fidelity versus conventional approaches, suggesting FAXP could accelerate biomarker discovery from existing clinical archives.