A team introduced Filter‑aided expansion proteomics (FAXP), combining tissue expansion chemistry with mass spectrometry to profile proteins at high resolution in formalin‑fixed, paraffin‑embedded (FFPE) samples. The method aims to extract cellular‑level proteomes from archival clinical tissue. Researchers demonstrated FAXP on complex tissues, reporting improved protein recovery and spatial resolution compared with standard FFPE workflows. The technique enables proteomic analysis of microenvironments within clinical specimens, potentially enhancing biomarker discovery and translational research using existing biobanks. Adoption will depend on reproducibility across labs, compatibility with diagnostic pipelines, and regulatory acceptance for use in companion‑diagnostic development.