Fecal microbiota transplantation (FMT), initially effective in treating recurrent Clostridioides difficile infections, is attracting research interest for broader applications including alopecia, depression, Parkinson’s disease, and Alzheimer’s disease. With over 1,300 publications in 2024 alone, FMT’s influence on systemic health via the gut microbiome has prompted investigations into diverse conditions influenced by microbial balance. Reports of side benefits, such as hair regrowth, underscore the complex biological impact and therapeutic potential of microbiome modulation.