A landmark study traced exosomal signatures that orchestrate lung‑tropic metastasis, identifying molecular cargo and microenvironment changes that favor colonization. The research used multiomics and functional assays to show how tumor‑derived vesicles condition distant lung tissue for metastatic seeding. Separately, lymphoma‑derived exosome analyses revealed host–tumor communication pathways that modulate immune responses. Together, the studies underscore exosomes as both biomarkers and potential therapeutic targets across multiple cancer types.