A Medical Oncology study decoded exosomal molecular signatures that drive tumor tropism to the lung, revealing how tumor‑derived extracellular vesicles condition lung microenvironments to support metastatic seeding. The research identified specific exosomal cargo and upstream signaling pathways that orchestrate organ‑selective dissemination. Authors combined proteomic and functional assays to link exosomal components with changes in pulmonary stromal cells and immune landscapes. The study provides candidate biomarkers for early detection of lung‑tropic metastasis and potential targets to disrupt pre‑metastatic niche formation. Translational groups and biotech teams can pursue exosome‑directed diagnostics or inhibitors as adjuncts to systemic therapy to prevent or detect lung metastasis earlier.