Researchers published a Nature Communications study showing engineered vesicles can boost oral antibiotic absorption while protecting the gut microbiome. The team designed vesicles that increase intestinal uptake of orally delivered antibiotics and reduce dysbiosis, addressing a key translational barrier for systemic oral formulations. The work demonstrates a co‑therapy approach where delivery vehicles modulate both pharmacokinetics and off‑target microbiome effects. The authors reported preclinical efficacy and mechanistic insights into vesicle uptake and microbiota preservation. If validated in larger animal models and early human trials, the platform could revive or improve oral formulations for drugs currently limited to parenteral routes and reduce microbiome‑related adverse events that complicate antibiotic use.