Danish researchers at DTU reported engineered Chinese hamster ovary (CHO) cell lines that synthesize threonine and histidine internally and exhibit reduced lactate and ammonia production. Published data in Nature Metabolism indicate these modifications simplify feeding regimens, lower waste metabolites, and could streamline biologics manufacturing by reducing process complexity and improving product quality. The team also demonstrated transferable strategies in HEK293 cells and plans to expand amino‑acid self‑sufficiency and evaluate impacts on antibody production and quality. If scalable, the approach could reduce media costs and variability for large‑scale biologics production and influence cell‑line engineering strategies across contract manufacturers and biopharma firms.