Researchers at Great Ormond Street Hospital and University College London reported functional integration of an autologous engineered esophagus in a large, growing porcine model. The 2.5‑cm grafts—decellularized donor scaffolds repopulated with autologous pericyte‑like myogenic precursors and fibroblasts—supported oral feeding and restored peristaltic function in survivors to six months. Bioreactor conditioning, biodegradable stents and vascularizing pleural wraps aided regeneration; histology showed progressive neuromuscular and vascular recapitulation. Authors frame the work as a translational step toward personalized grafts for infants with long‑gap esophageal atresia, offering a potential alternative to invasive reconstructive surgeries.