New studies illuminate asymmetry in the brain's glymphatic system as a correlate to the side of Parkinson’s disease symptom onset, advancing understanding of neurodegenerative mechanisms. Concurrent research reveals theta-frequency deep brain stimulation improves cognitive conflict resolution in Parkinson’s patients. A pilot trial also establishes the safety of fecal microbiota transplantation as a potential adjunctive therapy, collectively broadening therapeutic horizons for Parkinson’s management.