Strategic partnerships are propelling bioprocessing innovation through digitalization. Repligen’s collaboration with Novasign integrates advanced machine learning workflows into tangential flow filtration systems, unlocking potential for real-time predictive control and process optimization via digital twins. This fusion enhances process analytical technology deployment and accelerates scale-up efficiency. Concurrently, AI-driven tools are increasingly applied across bioprocessing sectors, including cultivation, harvest, and chromatography, heralding a new era of smarter, cost-effective therapeutic manufacturing.