Researchers at the Perelman School of Medicine (Penn) and Harvard reported in Science that an ultrathin, flexible electronic mesh implanted into developing pancreatic organoids recorded single‑cell electrical activity and delivered 24‑hour rhythmic stimulation that accelerated functional maturation of stem‑cell‑derived islet α and β cells. The device enabled longitudinal electrophysiology during differentiation and improved glucose‑responsive insulin secretion. Authors propose the approach as a pathway to generate more functional human islets for diabetes cell therapy and drug testing, while noting translational obstacles including biocompatibility, scale‑up and immunological protection for implanted tissue.