An international team led by Australia’s Walter and Eliza Hall Institute released a comprehensive atlas identifying 672 high‑confidence E3 ubiquitin ligases to serve as a reference for degrader drug discovery. The resource maps ligase expression and selectivity across tissues and will be used to broaden the set of ligandable E3s for proteolysis‑targeting chimera (PROTAC) and molecular glue programs. Authors say the atlas reduces a major bottleneck in targeted protein degradation by giving chemists and biologists a prioritized, biology‑driven list of E3s to pursue for disease‑relevant targets.