DUSP4 boosts antitumor CD8 T-cell function and CAR-T efficacy in colorectal cancer models

In colorectal cancer mouse models, DUSP4 (dual specificity phosphatase 4) enhanced antitumor CD8+ T-cell activity and improved CAR-T efficacy, according to a study published by Li, Koh, Zhang and colleagues. The report in the underlying article describes a countermeasure to a common limitation of solid-tumor CAR-T therapy—T-cell exhaustion or functional loss within the tumor microenvironment.