A research team demonstrated that encapsulating cisplatin with silibinin inside biodegradable PLGA polymeric nanoparticles improves antitumor efficacy in cervical cancer models compared with free drug. The co‑formulation enhanced tumor uptake, prolonged drug release, and increased apoptosis markers in treated tumors. Investigators presented pharmacodynamic data and tumor growth curves supporting superior tumor control and reduced systemic exposure. The approach targets combination chemotherapy delivery challenges and could lower dose‑limiting toxicities; next steps include scale‑up, GLP toxicology, and formulation stability studies to support clinical translation.