Memorial Sloan Kettering researchers report in Nature Cancer that disseminated cancer cells can enter a TGFβ‑driven program that ultimately transitions cells into a round, low‑tension morphology, allowing them to evade cytotoxic T lymphocyte mechanosurveillance. The lead authors, including Joan Massagué and Zhenghan Wang, demonstrate in a mouse model that reduced cortical tension impairs immune cell killing and helps dormant metastases persist. The team proposes that targeting the biomechanical state of dormant cells — preventing softening or re‑stiffening cells — could expose residual disease to immune clearance. This mechanistic insight links EMT programs and immune evasion and suggests a noncanonical target class for adjuvant therapies.