Researchers at Scripps Research and MIT reported a DNA‑origami‑based vaccine scaffold that elicits broadly neutralizing HIV antibodies in preclinical models. The platform uses DNA nanostructures to present viral antigens in precise geometries while avoiding undesired immune recognition of scaffold materials. Investigators said the approach could offer a modular route to generating the specific antigen arrangements needed to prime rare, broadly neutralizing B cell responses that have long frustrated HIV vaccine efforts. The work represents a material‑engineering approach to a longstanding immunogen design problem and may inform next‑generation vaccine candidates beyond HIV.