A University of Copenhagen team reported that amorphous lipid nanoparticles (LNPs) release therapeutic cargo more efficiently than highly organized particles, based on a high‑throughput single‑particle assay that measured size and payload across ~1 million nanoparticles. Presenting at the Biophysical Society meeting, lead author Artu Breuer showed that a minority subpopulation of ‘messy’ LNPs outperformed ordered particles in cellular delivery. The study challenges conventional formulation priorities that favor maximal cargo packing, suggesting that partial internal disorder can ease intracellular release by reducing stabilizing electrostatic interactions. The result has immediate implications for developers of LNP‑based mRNA therapies and rare disease payloads, where intracellular release efficiency is a critical bottleneck.