New single‑particle analyses presented at the Biophysical Society meeting found that lipid nanoparticles (LNPs) with internal disorder deliver RNA cargo more efficiently into cells than highly organized particles. The study by researchers at the University of Copenhagen measured individual particles and identified two subpopulations—organized and amorphous—finding the latter released payloads better in cellular assays. The findings challenge industry assumptions that tighter packing maximizes efficacy and suggest formulation strategies that favor controlled disorder could improve therapeutic index for mRNA treatments, particularly where high intracellular release is required such as oncology and rapidly dividing tissues.