New experimental work shows that a subpopulation of amorphous, disorganized lipid nanoparticles (LNPs) releases RNA cargo more efficiently inside cells than highly organized particles. A University of Copenhagen team developed a high‑throughput single‑particle assay and reported that the ‘messy’ LNPs outperformed structured counterparts in cellular delivery, addressing a long‑standing 1–5% release efficiency bottleneck for LNP therapeutics. The findings were presented at the Biophysical Society annual meeting and have been covered in multiple scientific outlets describing the single‑particle approach and implications for mRNA vaccines and therapies. Researchers argued that overly tight internal packing can impede intra‑cellular release, while partial disorder eases cargo dissociation when particles encounter the endosomal environment. Drug developers say the insight could shift formulation strategies—prioritizing functional release over maximum encapsulation—and may accelerate optimization of mRNA therapeutics for cancer, rare diseases, and protein replacement therapies.