A two-year implementation study at a major children’s cancer center reported that universal psychosocial screening across the pediatric cancer treatment trajectory is feasible, acceptable, and continuously improvable. The program generated 55 adaptations to move the Psychosocial Standard of Care from concept to routine workflow. The report details what it takes to operationalize screening beyond a one-time assessment, addressing longitudinal needs as care progresses. It provides a practical blueprint for institutions trying to incorporate psychosocial endpoints into standard clinical pathways. For pediatric oncology teams, the key development is scaling implementation: process refinement and integration appear to be the main hurdle rather than clinical intent.