A Nature Communications study led by Liu and colleagues found that dietary methionine restriction reversed kidney fibrosis in preclinical models through epigenetic remodeling. The investigators linked reduced methionine intake to changes in histone and DNA methylation states that attenuated fibrotic gene programs and improved renal pathology. The work ties a well‑defined nutritional manipulation to molecular epigenetic endpoints and functional kidney outcomes. The authors suggest methionine restriction as a candidate adjunctive strategy for chronic kidney disease, while noting that translation will require controlled clinical evaluation given the systemic effects of amino‑acid deprivation.