Researchers published a Nature Biotechnology study introducing DIAL (Dynamically Editable Artificial Loci), a programmable promoter‑editing framework that enables graded, reversible control of transgene expression. The paper details how DIAL can modulate expression levels beyond binary on/off control, enabling applications in synthetic biology and cell therapy manufacturing where fine‑tuned dosing of transgenes matters. In complementary work, CRISPR‑Cas9 screening approaches were adapted to probe non‑proliferative cell states, revealing candidate regulators that govern survival and phenotype in quiescent or terminally differentiated cells. These results expand the utility of functional genomics beyond dividing cells and identify targets that could shape therapies for tissues with low proliferation rates (CRISPR screens typically target DNA sequences to infer gene function).