A retrospective study suggests contrast-enhanced ultrasound (CEUS) can guide lung cancer biopsies when bronchoscopy fails or tumors are hidden within collapsed lung tissue. In 32 patients, CEUS helped delineate lesions and enabled definitive diagnosis despite limitations of conventional endoscopic access. The clinical utility centers on practical imaging reach—helping teams find targets when the airway route does not provide adequate visualization. For centers with CEUS capability, the findings support CEUS as a contingency pathway rather than a replacement for bronchoscopy in all settings. For oncology workflows, faster target visualization can reduce time-to-diagnosis, which is a major operational driver in treatment initiation.