A spatial genomics platform described as Slide-GoTags combines single-nucleus RNA sequencing, targeted transcript genotyping, and T cell receptor (TCR) sequencing from the same frozen tumor slice. The stated goal is to map neoantigen tumor cells alongside T cell colocalization to reveal where immune recognition is actually occurring within a patient’s tumor. The approach targets a practical limitation of cancer immunotherapy biomarker development: understanding not only which neoantigens are present, but whether and where corresponding T cells are spatially engaged. By integrating transcript and immune receptor data, the platform aims to improve the precision of immunotherapy selection and response assessment. For translational oncology groups, the key value proposition is spatial context at molecular resolution without requiring separate workflows across multiple sample types.