A retrospective study of geriatric diabetic foot patients reported that a simple score based on preoperative hemoglobin, platelet count, and albumin strongly discriminated 24-month mortality after major lower extremity amputation. The approach uses widely available labs rather than imaging or specialized biomarkers. The result positions risk stratification for post-amputation care as a tractable near-term translational target, potentially improving counseling, palliative planning, and resource allocation. For biotech and diagnostics developers, the study highlights continued demand for pragmatic prognostic tools that can be scaled without additional procedural burden.