Google’s DeepMind has released AlphaGenome, an AI model designed to predict the effects of small DNA sequence changes on gene regulation. Building on the success of AlphaFold in protein structure prediction, AlphaGenome integrates multiple genomic challenges into a unified model, offering powerful insights into DNA’s regulatory roles. Early users from Memorial Sloan Kettering Cancer Center have accessed the model and regard it as the most potent tool to date for in silico analysis of genetic variant effects, potentially accelerating genomic research and therapeutic target discovery.