Researchers at the Korea Research Institute of Chemical Technology demonstrated that inducing autophagy, a cellular degradation process, significantly shifts DNA repair from error-prone non-homologous end joining toward precise homologous recombination in CRISPR gene editing. This enhancement boosts editing accuracy by up to threefold across various cell types, addressing a major bottleneck in therapeutic genome engineering for genetic diseases. The strategy involves nutrient deprivation or mTOR inhibition to activate autophagy pathways, thereby promoting favorable DNA repair mechanisms.