Researchers at UCSF have demonstrated CRISPR activation to boost expression of the functional SCN2A gene in mice, restoring synapse function and improving neurodevelopmental outcomes relevant for human neurological disorders. Parallel efforts include an enhanced CRISPR diagnostics test for tuberculosis developed by Tulane University and Shenzhen Third People's Hospital. This improved assay uses a one-pot reaction combining RPA and CRISPR-Cas12a for rapid, sensitive detection from non-sputum samples, enabling affordable community screening in low-resource settings.