Significant shifts in U.S. vaccine policymaking occurred following Health and Human Services Secretary Robert F. Kennedy Jr.'s dismissal of all 17 members of the CDC’s Advisory Committee on Immunization Practices (ACIP), citing conflicts of interest and aimed at restoring public trust. The ousted experts have publicly contested this move, emphasizing ACIP’s rigorous vetting and its critical role in vaccine science. These events have raised concerns about potential disruptions to vaccine policy and public health achievements in immunization.