Two studies report micelle‑based delivery systems that enhance antifungal efficacy while lowering toxicity. Nature Biotechnology published a report on host‑defense peptide mimic micelles that co‑deliver antifungal drugs for effective combination therapy. Complementary work engineered self‑assembling peptide micelles that improve drug solubility and target fungal pathogens with reduced host toxicity. Both platforms demonstrated superior in vitro potency and improved therapeutic indices in animal infection models. Micelle‑based co‑delivery can concentrate drugs at infection sites and modulate pharmacokinetics, offering a pathway to revive existing antifungals or enable new combinations where systemic toxicity previously limited dosing. These approaches may address critical unmet need given rising invasive fungal disease and limited antifungal pipelines.