A JAMA-published adaptive clinical trial from University of Pittsburgh physician-scientists found refrigerated, chilled platelets can remain effective for up to 21 days, expanding the available supply window for bleeding patients. The results suggest chilled platelets performed as well as comparator approaches for controlling active bleeding. If confirmed in broader practice, the data could shift hospital workflows for platelet collection, storage, and allocation. It also challenges long-standing transfusion-medicine assumptions around temperature constraints for platelet efficacy. —