NIH-funded RECOVER-NEURO demonstrated feasibility for a centralized operating model to run multisite home-based digital therapy trials. The trial enrolled 328 participants across 22 US clinical sites, using local teams for recruitment and assessments while a central hub at NYU Langone Health handled device programming, kit preparation, remote supervision, adherence monitoring, and equipment recovery. Across 320 treated participants, 81.3% met consistent adherence during the 10-week intervention phase, supporting a scalable approach to reduce operational variability common in decentralized device-delivered study designs.