A new benchmarking framework aims to help clinical trial sites identify operational inefficiencies by standardizing evaluation across 36 performance benchmarks. The tool, developed from expert input across nine countries, is designed to compare site capabilities against an “ideal” while accounting for variations by trial phase and therapeutic area. Published in Therapeutic Innovation and Regulatory Science, the approach targets recurring pain points including patient recruitment, protocol adherence, and regulatory compliance. The authors used a structured survey process to select metrics that are both relevant and feasible to integrate into trial operations. Early applications suggest the system could flag inefficiencies that traditional evaluation methods miss, offering sponsors and sites a more consistent mechanism for quality improvement at the operational level.