Longer contact times on AAV affinity resins can materially shift yield and product purity, according to a report focused on binding kinetics. The study found extended binding times caused serotype-specific yield losses and enriched VP3, while sharply improving host-cell impurity clearance without compromising transgene integrity. From a development standpoint, the data targets a practical process lever that can reduce impurity burden—a major driver of downstream analytical work and release risk. The serotype-specific performance differences also reinforce that residence time optimization may need to be handled with program-specific parameter studies rather than applying a one-size-fits-all manufacturing schedule. For AAV sponsors, the implication is actionable: resin contact-time adjustments could enable tighter impurity control while maintaining genetic fidelity, but process characterization should be expanded to capture serotype-dependent behavior.