A randomized clinical trial in metastatic breast cancer found that alert-based patient-reported outcome (PRO) monitoring was associated with clinically meaningful reductions in fatigue and improvements in physical functioning. The results add to evidence that routine symptom tracking through digital tools can help oncology teams identify issues earlier. The trial supports the operational feasibility of PRO alerting as a care workflow rather than a standalone data project, aligning with goals of proactive symptom management in advanced disease settings. For clinicians and health systems, the findings strengthen the case for implementing PRO monitoring to improve quality-of-life outcomes alongside disease control.