The World Health Organization called for urgent scale-up of near point-of-care tuberculosis diagnostics, including a new class of nPOC molecular testing, ahead of World Tuberculosis Day. WHO’s guidance endorses nPOC nucleic acid amplification tests on sputum as initial diagnostics in adults and adolescents with signs or symptoms of pulmonary TB. The organization also recommends tongue swab sampling with nPOC-NAATs when sputum cannot be obtained and supports pooled expectorated sputum approaches where resources restrict testing of individual samples. WHO classified these as strong recommendations with moderate- or high-certainty evidence depending on the sampling or pooling strategy. WHO noted that a battery powered, isothermal amplification option from Pluslife meets performance criteria and referenced Cepheid’s Xpert MTB/RIF Ultra for pooled low-complexity automated NAAT strategies. WHO further emphasized preserving essential TB services amid funding constraints, noting that each dollar invested in TB can generate up to $43 in health and economic returns.