City of Hope launched HopeLLM, a proprietary generative AI platform that integrates multiple commercial and open-source models with the center’s extensive oncology data. HopeLLM automates administrative tasks such as new patient onboarding, matches patients to clinical trials, and generates personalized AI responses based on individual patient records. The tool also facilitates real-world data extraction for research purposes. This innovation aims to alleviate physician workloads, personalize patient care, accelerate research, and democratize access to top-tier cancer treatments across the nation.