City of Hope has developed HopeLLM, a proprietary generative AI platform that integrates diverse commercial and open-source AI models with extensive oncology data. The platform automates new patient intake, optimizes clinical trial matching, personalizes AI-generated patient responses, and facilitates extraction of real-world data to accelerate research. By reducing administrative burdens and advancing personalized treatment approaches, HopeLLM aims to enhance both provider efficiency and patient outcomes in cancer care.