City of Hope developed HopeLLM, a generative AI platform leveraging extensive oncology data to streamline clinical workflows and enhance patient personalization. The platform automates new patient onboarding, matches candidates to clinical trials, generates AI responses tailored to individual records, and extracts real-world data for research. This innovation aims to reduce physician administrative burden, improve clinical trial access, and accelerate breakthrough cancer research. The system integrates commercial and open-source AI models and was announced by City of Hope’s chief digital officer as a transformative healthcare innovation.