Researchers encapsulated cisplatin together with silibinin inside biodegradable PLGA polymeric nanoparticles and reported enhanced anticancer activity against cervical cancer models. The study showed improved drug delivery, sustained release, and synergistic tumor‑cell killing compared with free drugs, suggesting a formulation approach to increase cisplatin efficacy while potentially reducing systemic toxicity. Authors characterized nanoparticle physicochemical properties and demonstrated superior tumor uptake and cytotoxicity in vitro and in vivo. The approach could inform next‑generation combination chemotherapies where repurposed natural compounds like silibinin augment platinum‑based regimens and where polymeric carriers improve therapeutic index.